{"id":8380,"date":"2020-09-30T04:08:31","date_gmt":"2020-09-30T04:08:31","guid":{"rendered":"https:\/\/www.vc-news.com.cn\/?p=8380"},"modified":"2024-11-12T04:15:33","modified_gmt":"2024-11-12T04:15:33","slug":"%e8%b5%9b%e8%af%ba%e8%8f%b2%e5%87%ba%e4%bb%b734%e4%ba%bf%e7%be%8e%e5%85%83-%e6%94%b6%e8%b4%ad%e7%be%8e%e5%9b%bd%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e5%85%ac%e5%8f%b8principia","status":"publish","type":"post","link":"https:\/\/www.vc-news.com.cn\/?p=8380","title":{"rendered":"\u8d5b\u8bfa\u83f2\u51fa\u4ef734\u4ebf\u7f8e\u5143 \u6536\u8d2d\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Principia"},"content":{"rendered":"

\"\"<\/a>\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u540c\u610f\u4ee5\u5927\u7ea634\u4ebf\u7f8e\u5143\u6536\u8d2d\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Principia Biopharma Inc\uff0e\uff0c\u5728\u65b0\u4efb\u9996\u5e2d\u6267\u884c\u5b98Paul Hudson\uff0e\u7684\u9886\u5bfc\u4e0b\uff0c\u8d5b\u8bfa\u83f2\u8fd9\u5bb6\u6cd5\u56fd\u5236\u836f\u5546\u6b63\u5bfb\u6c42\u901a\u8fc7\u521b\u65b0\u7597\u6cd5\u6765\u523a\u6fc0\u589e\u957f\u3002<\/strong><\/h4>\n

\u6839\u636e\u8d5b\u8bfa\u83f2\u53d1\u8868\u7684\u4e00\u4efd\u58f0\u660e\uff0c\u5b83\u5c06\u901a\u8fc7\u8fd9\u7b14\u5168\u73b0\u91d1\u4ea4\u6613\u5b8c\u5168\u63a7\u80a1Principia Biopharma\uff0c\u540e\u8005\u4e13\u6ce8\u4e8e\u591a\u53d1\u6027\u786c\u5316\u75c7\u4ee5\u53ca\u5404\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/strong><\/p>\n

\u5f6d\u535a\u65b0\u95fb\u4e0a\u4e2a\u6708\u62a5\u9053\u79f0\uff0c\u8d5b\u8bfa\u83f2\u6b63\u5728\u7814\u7a76\u5bf9\u5305\u62ecPrincipia\u5728\u5185\u7684\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8\u7684\u6f5c\u5728\u6536\u8d2d\u3002<\/strong><\/p>\n

\u6839\u636e\u58f0\u660e\uff0c\u8d5b\u8bfa\u83f2\u5c06\u4e3a\u6bcf\u80a1Principia\u80a1\u7968\u652f\u4ed8100\u7f8e\u5143\u7684\u4ef7\u683c\uff0c\u8f83\u4e0a\u5468\u4e94\u6536\u76d8\u4ef7\u6ea2\u4ef710%\u3002Principia\u7684\u80a1\u4ef7\u4eca\u5e74\u4e0a\u6da8\u4e86\u8fd166%\u3002\u8d5b\u8bfa\u83f2\u8868\u793a\uff0c\u8fd9\u7b14\u4ea4\u6613\u7684\u603b\u80a1\u6743\u4ef7\u503c\u7ea637\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u5305\u62ecPrincipia\u6301\u6709\u7684\u73b0\u91d1\u3002<\/strong><\/h4>\n

\u8d5b\u8bfa\u83f2<\/strong>
\n\u5168\u7403\u9886\u5148\u533b\u836f\u4f01\u4e1a\u4e4b\u4e00<\/strong><\/h3>\n

\u8d5b\u8bfa\u83f2\u662f\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u533b\u836f\u5065\u5eb7\u4f01\u4e1a\uff0c\u4ee5\u60a3\u8005\u9700\u6c42\u4e3a\u672c\uff0c\u7814\u7a76\u4e36\u5f00\u53d1\u5e76\u63a8\u5e7f\u521b\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002\u8d5b\u8bfa\u83f2\u7684\u4e3b\u8981\u4e1a\u52a1\u6db5\u76d6\u4e09\u4e2a\u9886\u57df\uff1a\u5236\u836f\u4e36\u4eba\u7528\u75ab\u82d7\u548c\u52a8\u7269\u4fdd\u5065\u3002<\/strong><\/p>\n

2014\u5e74\uff0c\u8d5b\u8bfa\u83f2\u51c0\u9500\u552e\u989d\u8fbe337.70\u4ebf\u6b27\u5143\u3002\u8d5b\u8bfa\u83f2\u4e00\u76f4\u4ee5\u6765\u79c9\u627f\u5bf9\u4e2d\u56fd\u7684\u627f\u8bfa\u30021982\u5e74\uff0c\u8d5b\u8bfa\u83f2\u5728\u4e2d\u56fd\u5f00\u8bbe\u529e\u4e8b\u5904\uff0c\u8dfb\u8eab\u9996\u6279\u8fdb\u5165\u4e2d\u56fd\u7684\u8de8\u56fd\u5236\u836f\u4f01\u4e1a\u3002\u8d5b\u8bfa\u83f2\u76ee\u524d\u5728\u4e2d\u56fd\u62e5\u6709\u903e9,000\u540d\u5458\u5de5\uff0c\u662f\u4e2d\u56fd\u5883\u5185\u589e\u957f\u6700\u5feb\u7684\u533b\u836f\u5065\u5eb7\u4f01\u4e1a\u4e4b\u4e00\u3002<\/strong><\/h4>\n

Principia Biopharma Inc.<\/strong>
\n\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8<\/strong><\/h3>\n

Principia Biopharma Inc.\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u8be5\u516c\u53f8\u81f4\u529b\u4e8e\u4e3a\u60a3\u6709\u514d\u75ab\u5b66\u548c\u80bf\u7624\u5b66\u65b9\u9762\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u7684\u60a3\u8005\u5f00\u53d1\u53e3\u670d\u7597\u6cd5\u3002<\/strong><\/p>\n

\u8be5\u516c\u53f8\u4f7f\u7528\u5176Tailored Covalency\u5e73\u53f0\u8bbe\u8ba1\u548c\u5f00\u53d1\u53ef\u9006\u7684\u5171\u4ef7\u548c\u4e0d\u53ef\u9006\u7684\u5171\u4ef7\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3002\u8be5\u516c\u53f8\u7ba1\u9053\u5305\u62ecPRN1008\u4e36PRN1371\u548cPRN2246\u3002PRN1008\u5019\u9009\u836f\u7269\u4e13\u4e3a\u6cbb\u7597\u6162\u6027\u514d\u75ab\u75be\u75c5\u800c\u8bbe\u8ba1\u3002<\/strong><\/p>\n

PRN2246\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u5171\u4ef7BTK\u6291\u5236\u5242\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff09\u548c\u5176\u4ed6\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u75be\u75c5\u3002PRN1008\u4e5f\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u5929\u75b1\u75ae\u7b49\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002<\/strong><\/p>\n

PRN1371\u662f\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08FGFR\uff09\u7684\u6291\u5236\u5242\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u3002\u8be5\u516c\u53f8\u8fd8\u4e13\u6ce8\u4e8e\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53e3\u670d\u514d\u75ab\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u3002<\/strong><\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a, \u8bf7\u53c2\u9605 \u300a\u521b\u6295\u65f6\u4ee3\u300b(VCNews)
\n\u7535\u5b50\u62a5\u00a0www.vc-news.com.cn<\/a><\/strong><\/p>\n

\"\"<\/a><\/h4>\n

\"\"<\/a><\/p>\n

\u65b0\u51a0\u75c5\u6bd2\u75ab\u60c5\u91cd\u521b\u82f1\u56fd\uff08United Kingdom\uff09\u7ecf\u6d4e\uff0c\u623f\u5730\u4ea7\u4e1a\u5168\u9762\u505c\u6446\u3002\u5728\u653f\u5e9c\u5f00\u59cb\u5b9e\u65bd\u9632\u75ab\u5c45\u5bb6\u5c01\u9501\u540e\uff0c\u5168\u56fd\u7684\u623f\u5730\u4ea7\u4ea4\u6613\u6309\u4e0b\u6682\u505c\u952e\uff0c\u8d85\u8fc737.3\u4e07\u8d77\u6b63\u5728\u8fdb\u884c\u7684\u623f\u4ea7\u4ea4\u6613\u6682\u505c\uff0c\u6d89\u8d44820\u4ebf\u82f1\u9551\uff1b\u79df\u623f\u9700\u6c42\u4e5f\u4e0b\u964d\u8d85\u8fc740%\u3002<\/strong><\/p>\n

\u9762\u5bf9\u7ecf\u6d4e\u4f4e\u8c37\u548c\u5404\u65b9\u60b2\u89c2\u8bc4\u4f30\uff0c\u4e5f\u6709\u8d44\u6df1\u4e1a\u5185\u4eba\u58eb\u770b\u597d\u82f1\u683c\u5170\u623f\u5730\u4ea7\u7684\u53cd\u5f39\u6f5c\u529b\u3002<\/strong><\/p>\n

\u82f1\u56fd\u5e7f\u64ad\u516c\u53f8\uff08BBC\uff09\u4e2d\u6587\u5206\u522b\u91c7\u8bbf\u4e86\u4f26\u6566\u91d1\u878d\u57ce\u4e2d\u957f\u671f\u4ece\u4e8b\u623f\u5730\u4ea7\u4e1a\u5de5\u4f5c\u7684\u4e00\u4e9b\u4e13\u4e1a\u4eba\u58eb\uff0c\u5305\u62ec\u5168\u7403\u6700\u5927\u56fd\u9645\u5f8b\u5e08\u884c\u8d1d\u514b\u00b7\u9ea6\u575a\u65f6\uff08Baker McKenzie\uff09\u82f1\u56fd\u4e0d\u52a8\u4ea7\u90e8\u95e8\u7684\u5f8b\u5e08\u6731\u4e00\u6292\uff0c\u4ee5\u53ca\u4f2f\u514b\u5e0c\u5c14\u54c8\u6492\u97e6\u4e2d\u56fd\u533a\u8d1f\u8d23\u4eba\u7684\u97e6\u671d\u8d3a\u5148\u751f\u7b49\uff0c\u8bf7\u4ed6\u4eec\u5206\u6790\u4e86\u65b0\u51a0\u75c5\u6bd2\u75ab\u60c5\u5bf9\u82f1\u56fd\u623f\u5730\u4ea7\u5e02\u573a\u7684\u51b2\u51fb\uff0c\u4ee5\u53ca\u75ab\u60c5\u540e\u5e02\u573a\u7684\u8d70\u5411\u3002<\/strong><\/p>\n

\u636e\u6089\uff0c\u9762\u5bf9\u75ab\u60c5\u4e2d\u8d1f\u503a\u7d2f\u7d2f\u4e36\u5343\u75ae\u767e\u5b54\u7684\u7ecf\u6d4e\u73b0\u72b6\uff0c\u82f1\u56fd\u653f\u5e9c\u5df2\u5c06\u91cd\u632f\u623f\u5730\u4ea7\u5e02\u573a\u548c\u5efa\u7b51\u4e1a\u653e\u5728\u75ab\u60c5\u540e\u6062\u590d\u7ecf\u6d4e\u6d3b\u52a8\u7684\u91cd\u5934\u4f4d\u7f6e\uff1b\u7279\u522b\u662f\u5728\u5360\u82f1\u56fd\u4eba\u53e3\u548c\u7ecf\u6d4e\u6d3b\u52a8\u7edd\u5927\u591a\u6570\u7684\u82f1\u683c\u5170\u5730\u533a\uff0c\u56e0\u6b64\u4e0d\u5c11\u4e13\u4e1a\u4eba\u58eb\u9884\u8ba1\u623f\u5730\u4ea7\u5e02\u573a\u590d\u82cf\u53cd\u5f39\u6f5c\u529b\u5de8\u5927\u3002<\/strong><\/p>\n

\u75ab\u60c5\u9ad8\u5cf0\u521a\u521a\u8fc7\u53bb\u76845\u6708\u4e2d\u65ec\uff0c\u82f1\u56fd\u653f\u5e9c\u5728\u5c1a\u672a\u5168\u9762\u89e3\u5c01\u4e4b\u9645\uff0c\u5c31\u51b3\u5b9a\u91cd\u65b0\u5f00\u653e\u82f1\u683c\u5170\u5730\u533a\u7684\u623f\u5730\u4ea7\u5e02\u573a\uff0c\u5141\u8bb8\u6f5c\u5728\u4e70\u5bb6\u548c\u79df\u6237\u770b\u623f\u4ea4\u6613\u3002\u82f1\u683c\u5170\u5730\u533a\u7684\u623f\u5730\u4ea7\u7ecf\u7eaa\u4e36\u642c\u5bb6\u516c\u53f8\u548c\u4ea7\u6743\u8f6c\u8ba9\u4ea4\u6613\u673a\u6784\u5df2\u83b7\u51c6\u91cd\u65b0\u8425\u4e1a\uff0c\u524d\u63d0\u662f\u6709\u5173\u4eba\u5458\u8981\u9075\u5b88\u4fdd\u6301\u793e\u4ea4\u8ddd\u79bb\u7684\u89c4\u5b9a\u3002<\/strong><\/p>\n

\u8d1d\u514b\u00b7\u9ea6\u575a\u65f6\uff08Baker McKenzie\uff09\u5f8b\u5e08\u6240\u82f1\u56fd\u4e0d\u52a8\u4ea7\u90e8\u95e8\u5f8b\u5e08\u6731\u4e00\u6292\u8d1d\u548c\u4f2f\u514b\u5e0c\u5c14\u54c8\u6492\u97e6\u4e2d\u56fd\u533a\u8d1f\u8d23\u4eba\u7684\u97e6\u671d\u8d3a\u5206\u522b\u8868\u793a\uff0c\u76ee\u524d\u770b\u6765\uff0c2020\u5e74\u7684\u65b0\u51a0\u75c5\u6bd2\u75ab\u60c5\u5bf9\u82f1\u56fd\uff0c\u7279\u522b\u662f\u5bf9\u4f26\u6566\u7684\u623f\u5730\u4ea7\u5e02\u573a\u51b2\u51fb\u662f\u201c\u6682\u65f6\u7684\u201d\u3002\u4ed6\u4eec\u8ba4\u4e3a\uff0c\u7531\u4e8e\u82f1\u56fd\u571f\u5730\u79c1\u6709\uff0c\u4f9b\u7ed9\u957f\u671f\u4e0d\u8db3\u7684\u73b0\u72b6\u96be\u4ee5\u6539\u53d8\uff0c\u5e02\u573a\u4e0a\u65e0\u8bba\u662f\u5546\u4e1a\u5730\u4ea7\u8fd8\u662f\u4f4f\u5b85\u623f\u5730\u4ea7\u7684\u521a\u9700\u4ecd\u7136\u5b58\u5728\u3002<\/strong>\"\"<\/a><\/strong><\/h4>\n

\u82f1\u56fd\u8131\u6b27\u540e<\/strong>
\n\u4ecd\u662f\u56fd\u9645\u91d1\u878d\u4e2d\u5fc3<\/strong><\/h3>\n

\u6731\u4e00\u6292\u8bf4\uff0c\u82f1\u56fd\u8131\u6b27\u6ca1\u6709\u6539\u53d8\u4f26\u6566\u4f5c\u4e3a\u56fd\u9645\u91d1\u878d\u4e2d\u5fc3\u7684\u5730\u4f4d\uff0c\u4f5c\u4e3a\u6709\u7740\u826f\u597d\u5730\u4ea7\u5236\u5ea6\u73af\u5883\u548c\u6cd5\u5f8b\u4fdd\u969c\u7684\u82f1\u56fd\uff0c\u56e0\u4e3a\u82f1\u9551\u6c47\u7387\u4e00\u5ea6\u5927\u5e45\u5ea6\u4e0b\u8dcc\u76f8\u53cd\u5438\u5f15\u4e86\u5927\u91cf\u56fd\u9645\u6295\u8d44\u8fdb\u5165\u5730\u4ea7\u5e02\u573a\u3002\u51b5\u4e14\u5546\u4e1a\u5730\u4ea7\u6570\u91cf\u6709\u9650\uff0c\u56e0\u6b64\u5356\u65b9\u5e02\u573a\u7684\u603b\u4f53\u6001\u52bf\u4e00\u76f4\u6ca1\u6709\u6539\u53d8\u3002<\/strong><\/p>\n

\u5979\u8fd8\u6307\u51fa\uff0c2019\u5e74\u5e95\u82f1\u56fd\u5927\u9009\u4e2d\u4fdd\u5b88\u515a\u653f\u5e9c\u53d6\u5f97\u538b\u5012\u6027\u4f18\u52bf\u4e0a\u53f0\uff0c\u6295\u8d44\u4eba\u5bf9\u672a\u6765\u82f1\u56fd\u5546\u4e1a\u73af\u5883\u4fe1\u5fc3\u5927\u589e\uff0c\u672c\u6765\u6709\u671b\u8f83\u5feb\u7ed3\u675f2018\/19\u5e74\u4e70\u5356\u53cc\u65b9\u4e00\u5ea6\u89c2\u671b\u535a\u5f08\u7684\u5e02\u573a\u5e73\u9759\u65f6\u671f\uff0c\u53ea\u4e0d\u8fc7\u75ab\u60c5\u7684\u5230\u6765\u5ef6\u7f13\u4e86\u75ab\u60c5\u524d\u5df2\u7ecf\u4e0d\u65ad\u4e0a\u6da8\u7684\u4ea4\u6613\u9700\u6c42\u3002<\/strong><\/p>\n

\u82f1\u56fd\u56fd\u5bb6\u7edf\u8ba1\u5c40\u548c\u82f1\u56fd\u571f\u5730\u4ea4\u6613\u767b\u8bb0\u7f72\u6700\u65b0\u6570\u636e\u4f3c\u4e4e\u4e5f\u4e3a\u8fd9\u4e2a\u89c2\u70b9\u63d0\u4f9b\u4e86\u4e00\u4e9b\u8bc1\u636e\uff1a\u82f1\u56fd\u75ab\u60c5\u5c01\u9501\u524d\uff0c2020\u5e74\u521d\u4f26\u6566\u623f\u4ea7\u4ef7\u683c\u5f53\u65f6\u6b63\u4ee53\u5e74\u4ee5\u6765\u6700\u5feb\u7684\u901f\u5ea6\u4e0a\u626c\u3002<\/strong><\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a, \u8bf7\u53c2\u9605 \u300a\u521b\u6295\u65f6\u4ee3\u300b(VCNews)
\n\u7535\u5b50\u62a5\u00a0www.vc-news.com.cn<\/a><\/strong><\/h4>\n","protected":false},"excerpt":{"rendered":"

\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u540c\u610f\u4ee5\u5927\u7ea634\u4ebf\u7f8e\u5143\u6536\u8d2d\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Principia Biopharma Inc\uff0e\uff0c\u5728\u65b0\u4efb\u9996\u5e2d\u6267\u884c\u5b98Paul Hudson\uff0e\u7684\u9886\u5bfc\u4e0b\uff0c\u8d5b\u8bfa\u83f2\u8fd9\u5bb6\u6cd5\u56fd\u5236\u836f\u5546\u6b63\u5bfb\u6c42\u901a\u8fc7\u521b\u65b0\u7597\u6cd5\u6765\u523a\u6fc0\u589e\u957f\u3002 \u6839\u636e\u8d5b\u8bfa\u83f2\u53d1\u8868\u7684\u4e00\u4efd\u58f0\u660e\uff0c\u5b83\u5c06\u901a\u8fc7\u8fd9\u7b14\u5168\u73b0\u91d1\u4ea4\u6613\u5b8c\u5168\u63a7\u80a1Principia Biopharma\uff0c\u540e\u8005\u4e13\u6ce8\u4e8e\u591a\u53d1\u6027\u786c\u5316\u75c7\u4ee5\u53ca\u5404\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6cbb\u7597\u3002 \u5f6d\u535a\u65b0\u95fb\u4e0a\u4e2a\u6708\u62a5\u9053\u79f0\uff0c\u8d5b\u8bfa\u83f2\u6b63\u5728\u7814\u7a76\u5bf9\u5305\u62ecPrincipia\u5728\u5185\u7684\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8\u7684\u6f5c\u5728\u6536\u8d2d\u3002 \u6839\u636e\u58f0\u660e\uff0c\u8d5b\u8bfa\u83f2\u5c06\u4e3a\u6bcf\u80a1Principia\u80a1\u7968\u652f\u4ed8100\u7f8e\u5143\u7684\u4ef7\u683c\uff0c\u8f83\u4e0a\u5468\u4e94\u6536\u76d8\u4ef7\u6ea2\u4ef710%\u3002Principia\u7684\u80a1\u4ef7\u4eca\u5e74\u4e0a\u6da8\u4e86\u8fd166%\u3002\u8d5b\u8bfa\u83f2\u8868\u793a\uff0c\u8fd9\u7b14\u4ea4\u6613\u7684\u603b\u80a1\u6743\u4ef7\u503c\u7ea637\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u5305\u62ecPrincipia\u6301\u6709\u7684\u73b0\u91d1\u3002 \u8d5b\u8bfa\u83f2 \u5168\u7403\u9886\u5148\u533b\u836f\u4f01\u4e1a\u4e4b\u4e00 \u8d5b\u8bfa\u83f2\u662f\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u533b\u836f\u5065\u5eb7\u4f01\u4e1a\uff0c\u4ee5\u60a3\u8005\u9700\u6c42\u4e3a\u672c\uff0c\u7814\u7a76\u4e36\u5f00\u53d1\u5e76\u63a8\u5e7f\u521b\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002\u8d5b\u8bfa\u83f2\u7684\u4e3b\u8981\u4e1a\u52a1\u6db5\u76d6\u4e09\u4e2a\u9886\u57df\uff1a\u5236\u836f\u4e36\u4eba\u7528\u75ab\u82d7\u548c\u52a8\u7269\u4fdd\u5065\u3002 2014\u5e74\uff0c\u8d5b\u8bfa\u83f2\u51c0\u9500\u552e\u989d\u8fbe337.70\u4ebf\u6b27\u5143\u3002\u8d5b\u8bfa\u83f2\u4e00\u76f4\u4ee5\u6765\u79c9\u627f\u5bf9\u4e2d\u56fd\u7684\u627f\u8bfa\u30021982\u5e74\uff0c\u8d5b\u8bfa\u83f2\u5728\u4e2d\u56fd\u5f00\u8bbe\u529e\u4e8b\u5904\uff0c\u8dfb\u8eab\u9996\u6279\u8fdb\u5165\u4e2d\u56fd\u7684\u8de8\u56fd\u5236\u836f\u4f01\u4e1a\u3002\u8d5b\u8bfa\u83f2\u76ee\u524d\u5728\u4e2d\u56fd\u62e5\u6709\u903e9,000\u540d\u5458\u5de5\uff0c\u662f\u4e2d\u56fd\u5883\u5185\u589e\u957f\u6700\u5feb\u7684\u533b\u836f\u5065\u5eb7\u4f01\u4e1a\u4e4b\u4e00\u3002 Principia Biopharma Inc. \u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8 Principia Biopharma Inc.\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u8be5\u516c\u53f8\u81f4\u529b\u4e8e\u4e3a\u60a3\u6709\u514d\u75ab\u5b66\u548c\u80bf\u7624\u5b66\u65b9\u9762\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u7684\u60a3\u8005\u5f00\u53d1\u53e3\u670d\u7597\u6cd5\u3002 \u8be5\u516c\u53f8\u4f7f\u7528\u5176Tailored Covalency\u5e73\u53f0\u8bbe\u8ba1\u548c\u5f00\u53d1\u53ef\u9006\u7684\u5171\u4ef7\u548c\u4e0d\u53ef\u9006\u7684\u5171\u4ef7\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3002\u8be5\u516c\u53f8\u7ba1\u9053\u5305\u62ecPRN1008\u4e36PRN1371\u548cPRN2246\u3002PRN1008\u5019\u9009\u836f\u7269\u4e13\u4e3a\u6cbb\u7597\u6162\u6027\u514d\u75ab\u75be\u75c5\u800c\u8bbe\u8ba1\u3002 PRN2246\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u5171\u4ef7BTK\u6291\u5236\u5242\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff09\u548c\u5176\u4ed6\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u75be\u75c5\u3002PRN1008\u4e5f\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u5929\u75b1\u75ae\u7b49\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002 PRN1371\u662f\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08FGFR\uff09\u7684\u6291\u5236\u5242\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u3002\u8be5\u516c\u53f8\u8fd8\u4e13\u6ce8\u4e8e\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53e3\u670d\u514d\u75ab\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u3002 \u6b32\u4e86\u89e3\u66f4\u591a, \u8bf7\u53c2\u9605 \u300a\u521b\u6295\u65f6\u4ee3\u300b(VCNews) \u7535\u5b50\u62a5\u00a0www.vc-news.com.cn \u65b0\u51a0\u75c5\u6bd2\u75ab\u60c5\u91cd\u521b\u82f1\u56fd\uff08United Kingdo […]<\/p>\n","protected":false},"author":8,"featured_media":8382,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-8380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-34"],"_links":{"self":[{"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/8380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8380"}],"version-history":[{"count":2,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/8380\/revisions"}],"predecessor-version":[{"id":8386,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/8380\/revisions\/8386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=\/wp\/v2\/media\/8382"}],"wp:attachment":[{"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vc-news.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}